Integrative transcriptomics analysis reveals the metabolic regulatory functions of lncRNA in the livers of yak at different age stages.

ABSTRACT: Exploring the regulatory role of long non-coding RNA (lncRNA) in plateau yak is crucial to understanding its metabolic network for adapting to extreme environments. By integrating transcriptomic sequencing and co-expression network analysis, the messenger RNA (mRNA) and lncRNA expression characteristics of yak liver at three growth and development stages were systematically analyzed. A total of 35,216 mRNAs and 10,073 lncRNAs were detected. Among the 288 differentially expressed lncRNAs, 88 lncRNAs related to metabolism were screened, and their potential functions in lipid metabolism, collagen remodeling, and protein transport were predicted. The age-dependent expression patterns of some lncRNAs were verified through qRT-PCR (quantitative real-time reverse transcription polymerase chain re

SUBMITTER: Fu H 

PROVIDER: S-EPMC12507216 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature