Long-term outcomes of combination therapy with stereotactic body radiation therapy plus cryoablation using liquid nitrogen for stage I non-small cell lung cancer with tumors ≥2 cm.

ABSTRACT:

Objectives

Radiation and ablation therapy are used to treat stage I non-small cell lung cancer. However, the local control and survival rates remain unsatisfactory for tumors ≥2 cm. Therefore, this study explored the effectiveness of combination therapy of stereotactic body radiation plus cryoablation in this patient population.

Methods

This retrospective observational study included patients with stage I non-small cell lung cancer ≥2 cm who underwent stereotactic body radiation therapy followed by cryoablation between 2015 and 2023. All tumors were pathologically diagnosed before treatment. Patients received stereotactic body radiation therapy (40-60 Gy/4-10 fractions, median biological effective dose: 100 Gy), followed by cryoablation using liquid nitrogen within 3 weeks o

SUBMITTER: Nomori H 

PROVIDER: S-EPMC12507226 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature