Trends in incidence, mortality and disability-adjusted life years of colorectal cancer in East Asia (1990-2021): An analysis of the Global Burden of Disease study 2021.

ABSTRACT:

Background

Colorectal cancer (CRC) poses a significant health challenge in East Asia. This study examined long-term trends in CRC incidence, mortality and disability-adjusted life years (DALYs) and their key drivers across five East Asian countries (China, Japan, South Korea, North Korea and Mongolia) from 1990-2021.

Methods

Using Global Burden of Disease Study 2021 data, we assessed temporal trends using joinpoint regression, age/period/birth cohort effects through age-period-cohort analysis, and key drivers via decomposition analysis; we also evaluated associations between CRC burden and the Socio-Demographic Index (SDI).

Results

Between 1990 and 2021, descriptive analysis showed CRC age-standardised incidence rates (ASIRs) increased in all East Asian countries, whi

SUBMITTER: Cao Y 

PROVIDER: S-EPMC12507298 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature