Longitudinal modeling of red blood cell distribution width dynamics and mortality risk in critically Ill patients with sepsis-associated acute kidney injury.

ABSTRACT:

Background

Sepsis-associated acute kidney injury (SA-AKI) is a critical condition with high mortality. Red cell distribution width (RDW) has emerged as a potential dynamic biomarker, but longitudinal RDW changes in SA-AKI remain underexplored.

Methods

This retrospective cohort study analyzed adult SA-AKI patients from the MIMIC-IV database (2008-2022). Group-Based Trajectory Modeling (GBTM) identified distinct longitudinal RDW patterns. Primary outcome was 28-day all-cause mortality. Secondary outcomes included 90-day mortality, continuous renal replacement therapy (CRRT) requirement, and ICU length of stay. Multivariable Cox models assessed associations. adjustment for any transfusion and any major hemorrhage, and an exclusion analysis in which all transfused patients were

SUBMITTER: He R 

PROVIDER: S-EPMC12507301 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature