Motor performance as a predictor of blood levels of ammonia and inflammatory biomarkers in patients with liver cirrhosis.

ABSTRACT: Liver cirrhosis can present with complications such as hyperammonemia and inflammation, and the consequent appearance of minimal hepatic encephalopathy (MHE), which has been associated with poorer motor performance. Our aim was to analyze whether motor impairment would predict blood levels of ammonia and inflammatory factors in cirrhotic patients, independently of cognitive impairment. Blood was extracted from 67 cirrhotic patients from two hospitals in Valencia (Spain) (41.79% with MHE, diagnosis by Psychometric Hepatic Encephalopathy Score). Blood ammonia and plasma levels of interleukins (IL-6, IL-13, IL-18, IL-21, IL-22, IL-23, TNF-α, TGF-β) and chemokines (CCL20, CX3CL1, CXCL13, CCL2) were measured by micro-diffusion and ELISA, respectively. Gait, balance, hand strength, and manual mo

SUBMITTER: San Martin Valenzuela C 

PROVIDER: S-EPMC12507304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature