Optimal Cerebral Perfusion Pressure in Brain Injury: Physiological Relationships and Outcome.

ABSTRACT:

Background and objectives

The priority for measuring and optimizing physiological metrics in brain injury care remains to be determined. Calculating and targeting optimal cerebral perfusion pressure (CPP opt ) is an emerging treatment paradigm, but its association with other parameters is uncertain. A previous analysis of 22 patients found that brain tissue oxygenation (P bt O 2 ) peaked when CPP values were near CPP opt . This study sought to validate those findings using a distinct, larger cohort. It also studied the relationship between CPP opt and physiological parameters related to intracranial dynamics and with neurological outcome.

Methods

P bt O 2 , intracranial pressure (ICP), and arterial blood pressure data were collected during a 15-year period from 432 brain inj

SUBMITTER: Pelah AI 

PROVIDER: S-EPMC12507320 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature