Association of age with survival in older patients with cutaneous melanoma treated with immune checkpoint inhibitors.

ABSTRACT:

Introduction

Several types of immune checkpoint inhibitors (ICIs) are approved to treat advanced melanoma, but their effectiveness has not been compared in older patients treated outside of a clinical trial. Moreover, evidence suggests that a patient's response to ICI therapy may vary by age and type of ICI. The purpose of this study was to compare survival by ICI type in older patients with melanoma and to investigate treatment effect modification by age.

Materials and methods

Using the SEER-Medicare database, we identified patients with cutaneous melanoma (2012-2015) treated with an ICI (CTLA-4, PD-1, or combination CTLA-4 + PD-1 inhibitors). Cox proportional hazards regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for ICI types. We us

SUBMITTER: Howell AV 

PROVIDER: S-EPMC12507325 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature