APOE4 Exacerbates Alzheimer-Like Pathologies and Cognitive Deficits Induced by Blood-Derived Aβ in a Mouse Model.

ABSTRACT: Apolipoprotein E4 (APOE4) is a significant risk for both familial Alzheimer's disease (AD) and sporadic AD with elusive mechanisms. Previous studies mainly focused on the role of APOE4 in familial AD, with less attention to sporadic AD. Our previous study demonstrated that blood cell-derived amyloid-β (Aβ) can enter the brain and induce AD-like pathologies, providing a novel animal model to study sporadic AD to a certain extent. The impacts of APOE4 on Alzheimer-like pathologies and cognitive deficits induced by blood-derived Aβ remain unknown. In the present study, we found that APOE4 prompted the entry of blood Aβ into the brain. APOE4 recipient mice showed impaired integrity of the blood-brain barrier and higher Aβ levels in the brain after transplantation of bone marrow cells from APP/

SUBMITTER: Yu ZY 

PROVIDER: S-EPMC12507402 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature