Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma.

ABSTRACT: Strategies to slow the aging process or mitigate its consequences on health rely on the validation of minimally-invasive biomarkers of aging that can be used to track aging and test the effectiveness of antiaging interventions. Study of aging in a nonhuman primate species offers a robust translational approach to achieving these aims, avoiding wide differences in genetics and environmental exposures that confound human aging studies. As epigenetic age appears to predict biological aging, biomarkers linked to epigenetic aging should be especially valuable in identifying individual differences in aging progression and documenting the impact of antiaging strategies. Proteins are the final effectors in most signaling pathways, indicating that alteration in levels of circulating proteins potent

SUBMITTER: Elsworth JD 

PROVIDER: S-EPMC12507418 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature