T-CLASS: An Online Tool for the Identification and Classification of Aging and Senescence Using Transcriptome Data.

ABSTRACT: Transcriptome analysis has become increasingly utilized in aging research. However, the identification of the key molecular changes underlying aging processes and longevity-promoting regimens from transcriptome data remains challenging. Here, we present Transcriptomic CLassification via Adaptive learning of Signature States (T-CLASS), an online tool that identifies, from transcriptome data, gene sets of several hundred genes that provide an optimal representation of longevity and aging paradigms. We systematically evaluated the effectiveness of T-CLASS with diverse datasets, including longevity-promoting regimens in Caenorhabditis elegans, cellular senescence by different means in both cultured mouse primary cells and cultured human cells, and human sarcopenia. We found that T-CLASS exhibi

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC12507419 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature