Coarse-Grained Modeling Elucidates Differential Metabolism of <i>Saccharomyces cerevisiae</i> under Varied Nutrient Limitations.

ABSTRACT: Microorganisms such as Saccharomyces cerevisiae have a native ability to adapt their metabolism to varying nutrient conditions. Understanding their responses to nutrient limitations is critical for decoding cellular physiology and designing strategies for metabolic engineering. While the influence of carbon availability on yeast metabolism has been extensively studied, the role of nitrogen availability remains relatively underexplored. In this study, we utilized a coarse-grained kinetic model to systematically analyze and compare the effects of carbon and nitrogen limitations on yeast metabolism. Our model successfully revealed the differential metabolic characteristics of S. cerevisiae under carbon- and nitrogen-limited chemostat conditions. It also highlighted the significa

SUBMITTER: Li Y 

PROVIDER: S-EPMC12507479 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature