The influence of <i>Pseudomonas aeruginosa</i> infection on the airway metabolome.

ABSTRACT: Pseudomonas aeruginosa is an environmentally resilient bacterium and an important cause of both acute and chronic infections in people with impaired natural barriers or immunological defences. Chronic respiratory infection with P. aeruginosa is a major cause of morbidity and mortality in people with airway diseases, including cystic fibrosis (CF) and non-CF bronchiectasis. Chronic airway infection is characterized by periods of relative stability punctuated by pulmonary exacerbations, during which times rapid bacterial outgrowth necessitates intense antimicrobial chemotherapy. The periods of stable infection can be modelled in mice by nasal instillation of airway-adapted P. aeruginosa in saline, leading to prolonged colonization of both upper airway (sinus) and lower a

SUBMITTER: Green AE 

PROVIDER: S-EPMC12507523 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature