Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders.

ABSTRACT:

Introduction

Distinguishing behavioral variant frontotemporal dementia (bvFTD) from primary psychiatric disorders (PPDs) remains challenging due to overlapping clinical presentation. Neurofilament light chain (NfL) is a biomarker of neuronal damage that is elevated in neurodegenerative diseases. This study assessed the effectiveness of NfL and atrophy in differentiating bvFTD from PPDs.

Methods

Atrophy maps from frontotemporal regions were generated for 55 patients with autopsy-confirmed frontotemporal lobar degeneration (bvFTD-FTLD), 24 mood disorder patients, and eight bvFTD patients later determined to be non-neurodegenerative (bvFTD-nonND). Logistic regression was employed to assess the discriminatory abilities of atrophy and NfL levels between bvFTD-FTLD and PPD (Mood D

SUBMITTER: Coulborn S 

PROVIDER: S-EPMC12507538 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature