Dynamic immune and molecular responses to chronic heat stress in blood and peripheral blood mononuclear cells of dairy cows.

ABSTRACT:

Background

As a result of climate change, dairy cows even in confinement systems are exposed to high ambient temperatures and environmental factors inducing heat stress. However, there are indications that chronic heat stress with reduced feed intake initially stimulates a systemic inflammatory response and progressively reduces the immunocompetence. This finally increases the disease susceptibility. This study aimed to elucidate the effects of chronic heat stress or equivalent reduced feed intake via pair-feeding at thermoneutrality on the daily hematological profile, leukocyte NF-κB p65 signaling pathway, immune function, and metabolism in peripheral blood mononuclear cells (PBMC) of dairy cows.

Methods

Primiparous, mid-lactating Holstein cows (n = 30) were assigned

SUBMITTER: Koch F 

PROVIDER: S-EPMC12507569 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature