Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses.

ABSTRACT: Roughly 10.8% (>26 million) Americans suffer from food allergies (FA) which, in severe cases, can be life threatening. Oral immunotherapy (OIT) offers a promising allergen-specific approach in the management of FA. However, due to risk of anaphylactic shock, there are significant concerns regarding its safety and must be carried out in the hospital under careful supervision by clinicians. These concerns may be addressed through delivery of the allergen in engineered nanoparticulate packages which may additionally improve therapeutic efficacy. Polysaccharide A (PSA), a commensal-derived molecule produced by the gut-symbiont Bacteroides fragilis, has shown tremendous potency in ameliorating inflammatory diseases in various mouse models by eliciting tolerogenic T cell activity. The tol

SUBMITTER: Harriman R 

PROVIDER: S-EPMC12507582 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature