U-shaped association between triglyceride-glucose index and acute kidney injury in critically ill children with cardiac diseases.

ABSTRACT:

Background

The triglyceride-glucose (TyG) index, a surrogate of insulin resistance (IR), has been linked to acute kidney injury (AKI) in adults, but its relevance in critically ill children with cardiac disease is unclear. This study aimed to examine this relationship in this vulnerable population.

Methods

This retrospective analysis drew on data from the Pediatric Intensive Care (PIC) database, comprising 2298 critically ill children treated in the Cardiac Intensive Care Unit (CICU) between 2010 and 2019. The primary outcome was the AKI incidence, whereas secondary outcome focused on the occurrence of severe AKI. Restricted cubic splines (RCS) assessed nonlinearity. Multivariate two-segment Cox regression analyses estimated hazard ratios (HRs) across TyG segments after adju

SUBMITTER: Du J 

PROVIDER: S-EPMC12507589 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature