Global, regional, and national burden of hyperglycemia-associated colorectal cancer, 1990-2021: a systemic analysis for the Global Burden of Disease study.

ABSTRACT:

Background

Colorectal cancer (CRC) is a leading gastrointestinal malignancy with rising incidence. Hyperglycemia emerges as a critical driver of CRC progression, yet its global disease burden, particularly regarding health inequality and years lived with disability (YLDs), remains underexplored.

Methods

This study leverages the Global Burden of Disease (GBD) 2021 dataset to analyze hyperglycemia-associated CRC burden across 21 regions and 204 countries from 1990 to 2021. It incorporates deaths, disability-adjusted life years (DALYs), YLDs, and years of life lost (YLLs), employing hierarchical clustering and health inequality metrics like the slope index of inequality and concentration index. Projections for 2022-2040 are generated using age-period-cohort models.

Results</

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12507591 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature