Efficacy and safety of lubiprostone combined with polyethylene glycol electrolyte powder for bowel preparation in patients classified by risk level: a randomised trial.

ABSTRACT:

Objective

This study aimed to assess the efficacy and safety of lubiprostone combined with polyethylene glycol (PEG) electrolyte powder for bowel preparation in patients classified by risk level.

Methods

The following factors were considered to be associated with inadequate bowel preparation: constipation (meeting Rome IV criteria), BMI > 25 kg/m², history of inadequate bowel preparation, colorectal surgery, diabetes, stroke, or spinal cord injury, Parkinson's disease, and use of tricyclic antidepressants or anesthetics. A total of 424 patients scheduled for colonoscopy were included and categorized into high-risk and low-risk groups based on bowel preparation risk factors. These patients were then randomly assigned to block groups. The high-risk group was further subdivided

SUBMITTER: Song J 

PROVIDER: S-EPMC12507641 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature