Rewiring of cortical glucose metabolism fuels human brain cancer growth.

ABSTRACT: The brain avidly consumes glucose to fuel neurophysiology¹. Cancers of the brain, such as glioblastoma, relinquish physiological integrity and gain the ability to proliferate and invade healthy tissue². How brain cancers rewire glucose use to drive aggressive growth remains unclear. Here we infused ¹³C-labelled glucose into patients and mice with brain cancer, coupled with quantitative metabolic flux analysis, to map the fates of glucose-derived carbon in tumour versus cortex. Through direct and comprehensive measurements of carbon and nitrogen labelling in both cortex and glioma tissues, we identify profound metabolic transformations. In the human cortex, glucose carbons fuel essential physiological processes, including tricarboxylic acid cycle oxidation a

SUBMITTER: Scott AJ 

PROVIDER: S-EPMC12507665 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature