Predicted deleterious mutations reveal the genetic architecture of male reproductive success in a lekking bird.

ABSTRACT: Deleterious mutations are ubiquitous in natural populations and, when expressed, reduce fitness. However, the specific nature of these mutations and the ways in which they impact fitness remain poorly understood. We exploited recent advances in genomics to predict deleterious mutations in the black grouse (Lyrurus tetrix), an iconic lekking species. Analysis of 190 whole genomes alongside comprehensive life-history data including repeated measures of behavioural, ornamental and fitness traits revealed that deleterious mutations identified through evolutionary conservation and functional prediction are associated with reduced male lifetime mating success. Both homozygous and heterozygous deleterious mutations reduce fitness, indicating that fully and partially recessive mutations contribute

SUBMITTER: Chen RS 

PROVIDER: S-EPMC12507671 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature