TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function.

ABSTRACT: B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial^1-3. The CD5⁺ B-1a subset expresses anti-inflammatory molecules including IL-10, PDL1 and CTLA4 and can be immunoregulatory^4-6. Unlike conventional B cells that are continuously replenished, B-1a cells are produced early in life and maintained through self-renewal⁷. Here we show that the transcription factors TCF1 and LEF1 are critical regulators of B-1a cells. LEF1 expression is highest in fetal and bone marrow B-1 progenitors, whereas the levels of TCF1 are higher in splenic and peritoneal B-1 cells than in B-1 progenitors. TCF1-LEF1 double deficient mice have reduced B-1a cel

SUBMITTER: Shen Q 

PROVIDER: S-EPMC12507693 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature