Heat-rechargeable computation in DNA logic circuits and neural networks.

ABSTRACT: Metabolism enables life to sustain dynamics and to repeatedly interact with the environment by storing and consuming chemical energy. A major challenge for artificial molecular machines is to find a universal energy source akin to ATP for biological organisms and electricity for electromechanical machines. More than 20 years ago, DNA was first used as fuel to drive nanomechanical devices^1,2 and catalytic reactions³. However, each system requires distinct fuel sequences, preventing DNA alone from becoming a universal energy source. Despite extensive efforts⁴, we still lack an ATP-like or electricity-like power supply to sustain diverse molecular machines. Here we show that heat can restore enzyme-free DNA circuits from equilibrium to out-of-equilibrium state

SUBMITTER: Song T 

PROVIDER: S-EPMC12507696 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature