Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.

ABSTRACT: Alcohol-associated liver disease (ALD) represents a major global health concern due to its significant contribution to morbidity and mortality. The development of ALD is largely driven by oxidative stress, inflammation, and apoptosis. Shikonin (SKN) is a natural extract possessing both antioxidant and anti-inflammatory properties. This study investigated the protective effects of SKN against ALD in an in vivo rat model of ALD induced by daily gavage with 52% alcohol for 6 weeks. Following this, SKN was administered, and its antioxidant, anti-inflammatory, and anti-apoptotic properties were examined. Results demonstrated that SKN treatment inhibited the alcohol-induced increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol

SUBMITTER: Gan H 

PROVIDER: S-EPMC12507725 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature