Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis.

ABSTRACT:

Background

Recent studies indicate that older adults (aged 55 years and above) represent a critical period for changes in circulating brain derived neurotrophic factor (BDNF) levels and cognitive function. Regular aerobic exercise (AE) has been recognized as a promising non-pharmacological strategy to influence neuroplasticity and cognitive function, primarily through the regulation of BDNF. However, inconsistent findings have been reported regarding the specific effects of three AE modalities-walking, running, and cycling-on circulating BDNF levels in older adults. This study aimed to systematically evaluate the effects of these AE modalities on BDNF levels in the elderly through a meta-analysis, and to further compare the relative effectiveness of various exercise protocols using

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC12507801 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature