Efficacy and safety of anlotinib in the treatment of brain metastases from non-small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

The presence of brain metastases is a significant factor contributing to the failure of lung cancer therapies. This study aims to systematically assess the efficacy and safety of anlotinib in the treatment of brain metastases resulting from non-small cell lung cancer (NSCLC).

Methods

A comprehensive literature search was conducted across multiple databases, including PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wan fang, and VIP databases. This search encompassed the period from the establishment of the databases up until November 2024. The Cochrane risk of bias tool was employed to assess the quality of the randomized controlled trials (RCTs) included in the study, while the quality of the cohort studies was evaluated using the Newcastle-Ottawa Scale (

SUBMITTER: Fang C 

PROVIDER: S-EPMC12507809 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature