Transcriptomic and proteomic profiling of <i>Actinobacillus pleuropneumoniae</i> responses to iron starvation.

ABSTRACT:

Background

Actinobacillus pleuropneumoniae (APP) is the causative agent of porcine contagious pleuropneumonia, which remains a major pathogen endangering the swine industry. However, the mechanisms underlying its colonization and pathogenesis in pigs remain largely unknown.

Methods

An integrated analysis combining transcriptomic and proteomic profiling was employed to detect genetic and protein changes in APP under iron starvation.

Results

In total, 458 differentially expressed genes (DEGs) from the transcriptome and 532 differentially expressed proteins (DEPs) from the proteome were identified. The comparative analysis showed that 137 differentially expressed genes/proteins were shared between DEGs and DEPs, with the majority exhibiting consistent regulatory c

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12507848 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature