Anti-inflammatory and antioxidant effects of <i>Pogostemon stellatus</i> (Lour.) Kuntze via MAPK, NF-κB, and Nrf2 signaling pathways in LPS-activated RAW 264.7 macrophages.

ABSTRACT:

Background

Pogostemon stellatus (Lour.) Kuntze is a plant native to South and East Asia belonging to the Lamiaceae family, whose members are widely recognized for their anti-inflammatory and antioxidant properties. However, these properties have not been extensively studied in P. stellatus (Lour.) Kuntze. This study aimed to evaluate the anti-inflammatory and antioxidant effects of methanol extract of P. stellatus (Lour.) Kuntze (MPSK) in LPS-stimulated RAW 264.7 macrophages.

Methods

RAW 264.7 macrophages were stimulated with LPS and treated with MPSK. Anti-inflammatory effects were assessed by measuring nitric oxide (NO) and prostaglandin E₂ (PGE₂) levels and the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2),

SUBMITTER: Yoon H 

PROVIDER: S-EPMC12507890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature