Acute air pollution exposure and gastrointestinal cancer mortality: a case-crossover study in coastal China.

ABSTRACT:

Background

Gastrointestinal (GI) cancers account for 43.1% of cancer-related deaths in China, with aging populations exacerbating this burden. While chronic air pollution exposure is linked to GI carcinogenesis, evidence on acute effects remains limited. This study investigates short-term ambient pollutant exposure and GI cancer mortality in a coastal Chinese city with moderate pollution levels.

Methods

Using death registry data from Yancheng, China (2013-2022; n = 104,216 GI cancer deaths), we employed a time-stratified case-crossover design combined with distributed lag nonlinear models (DLNM) to assess associations between daily PM_2.5, PM₁₀, SO₂, NO₂, and O₃ concentrations (lag 0-7 days) and mortality. Stratifi

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12507895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature