Elevated novel inflammatory markers in heart failure patients are associated with increased risk of adverse outcomes within one year: insights from a longitudinal study.

ABSTRACT:

Background

Inflammation has been widely recognized as a key contributor to the pathogenesis of numerous diseases, including cardiovascular disorders. This study aims to investigate the associations between different novel inflammatory markers and adverse outcomes within one year in patients with HF, and to identify the most effective predictor.

Methods

Three inflammatory markers-Systemic Inflammatory Response Index (SIRI), Systemic Immune-Inflammatory Index (SII), and Neutrophil-to-Lymphocyte Ratio (NLR)-were evaluated. Cox regression analysis was performed to examine their associations with adverse outcomes within one year. Kaplan-Meier (KM) survival analysis was used to estimate the cumulative risk of adverse events. Additionally, receiver operating characteristic (ROC) cu

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12507900 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature