The reticulocyte restriction: invasion ligand RBP1a of <i>Plasmodium vivax</i> targets human TfR1, prohibitin-2, and basigin.

ABSTRACT:

Introduction

Plasmodium vivax is the most widespread cause of malaria outside Africa. Developing effective controls is challenging because P. vivax exclusively invades reticulocytes, immature erythrocytes that are scarce and short-lived. This limits opportunities to culture the parasite and investigate the receptor-ligand interactions crucial for host cell invasion.

Methods

The erythroid cell lines JK-1 and BEL-A were evaluated in vitro as reticulocyte surrogates to assess their susceptibility to P. vivax invasion. Comparative membrane proteomics of these cell lines, reticulocytes, and mature erythrocytes were performed using quantitative liquid chromatography-mass spectrometry (LC-MS). Specific interactions between the parasite ligand PvRBP1a (re

SUBMITTER: Molina-Franky J 

PROVIDER: S-EPMC12507909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature