Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction.

ABSTRACT:

Introduction

In human neurocysticercosis (NCC), the cellular and molecular mechanisms of host-parasite interactions triggering brain inflammation and epileptic seizures in Sub-Saharan Africa are poorly understood. Emerging evidence indicates that the viability of the cyst of the pork tapeworm Taenia solium determines brain inflammation and, thus, symptom development and disease severity. We have previously shown that while viable cyst-released molecules promote immune regulation and often asymptomatic disease, the fluid from degenerating cysts causes inflammation in microglia and peripheral immune cells, potentially driving immune-mediated pathology. This study aims to elucidate the apoptotic signaling pathways underlying this process and their relevance for symptomatic dise

SUBMITTER: Sternkopf LE 

PROVIDER: S-EPMC12507911 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature