Topical delivery of meropenem via spanlastic carbopol gel: <i>in-vitro</i> studies and <i>in-vivo</i> application in pressure ulcers.

ABSTRACT:

Introduction

Spanlastics, a type of elastic nanovesicle, represents a promising drug delivery system capable of encapsulating both hydrophilic and lipophilic drug compounds. These carriers are biodegradable, biocompatible, and non-immunogenic. Meropenem (MRP), a broad-spectrum carbapenem antibiotic, is widely used to treat severe infections in both adults and children before the causative pathogens are identified. However, meropenem's aqueous formulations are highly unstable and must be administered within 24 h of preparation. This study aimed to develop a meropenem-loaded spanlastic formulation (MRP-SP) for topical application, aiming to enhance both the drug's stability and skin permeability.

Methods

Spanlastics were prepared using Span 60 and Brij 35 via the ethanol injec

SUBMITTER: Abdelfattah S 

PROVIDER: S-EPMC12507946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature