In vitro skin permeation of mitragynine: Optimisation of antioxidants for enhanced drug stability and formulation performance.

ABSTRACT: The opioid-like characteristics of mitragynine with biased μ-opioid receptor activation are attractive for pain and addiction therapy due to less addictive issue. Our previous work has shown the potential of delivering mitragynine through the skin but drug degradation hindered a reliable understanding of its permeation behaviour. This study aims to optimise the use of antioxidants in both the receptor medium and formulations for in vitro permeation studies of mitragynine (5%w/v) using single solvent systems. The optimised receptor medium with 0.01%w/v of ascorbic acid in phosphate buffer saline was chosen due to a high mitragynine recovery that also allowed the detection of a higher mitragynine amount permeated. Dimethyl sulphoxide and Transcutol^® achieved the highest mitragynin

SUBMITTER: Sim YS 

PROVIDER: S-EPMC12507957 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature