Pharmaceutical Co-crystal of Ketoconazole-adipic Acid: Excipient Compatibility and In Silico Antifungal Potential Studies.

ABSTRACT:

Objective

This research aimed to investigate the compatibility of the Ketoconazole-Adipic Acid (KTZ-AA) co-crystal, which exhibits an improved dissolution profile over pure Ketoconazole, with various solid pharmaceutical excipients, as well as its in silico antifungal potential.

Methods

Binary physical mixtures (1:1 w/w) of KTZ-AA co-crystal and excipients were analyzed using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD). The molecular docking study targeting the sterol 14α-demethylase (CYP51) enzyme of the pathogenic yeast Candida albicans was performed.

Results

DSC results indicated compatibility between co-crystal and six tested excipients: lactose mono

SUBMITTER: Martin F 

PROVIDER: S-EPMC12507965 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature