Assessment of a Semi-solid Extrusion Based Compounding System Solution for Personalized Ondansetron Dosage Forms Combined with Raman Spectroscopy Analysis.

ABSTRACT:

Objective

3D printing and extrusion-based technologies, especially semi-solid extrusion (SSE), are promising solutions to fulfil the need to personalize pediatric medicines. In this study an automated SSE based Compounding System Solution (CSS) technology was assessed for creating customized Ondansetron tablets. Additionally, a non-destructive quality control method for the customized Ondansetron tablets was developed by utilizing Raman Spectroscopy (RS) measurements and partial least square (PLS) analysis.

Methods

Tablets of 400 mg with varying Ondansetron content (2-10 mg) and different sizes (200-500 mg) with 0.5% Ondansetron were manufactured and tested according to European and US Pharmacopoeia standards, HPLC, and the RS-based PLS model.

Results

The mass uniform

SUBMITTER: Bahman M 

PROVIDER: S-EPMC12507975 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature