Pituitary Neuroendocrine Tumor or Pituitary Adenoma? Let's Ask the Epigenome!

ABSTRACT: The introduction of the term pituitary neuroendocrine tumor (PitNET) to replace pituitary adenoma has sparked a versatile debate among experts. The controversy surrounding this nomenclature change includes the question of whether these tumors' biological identity truly corresponds to neuroendocrine tumors. In this meta-analysis, DNA methylation data were interrogated to clarify whether the old or new nomenclature more accurately reflects the epigenome of these tumors. Publicly available DNA methylation data of 100 NETs, 100 PitNETs/adenomas, and 100 adenomas of various origins and lineages were compiled from 18 different publications. Epigenomic signatures characteristic of NETs and adenomas were defined and compared to those of PitNETs/adenomas. Promoter CpG methylation levels were invest

SUBMITTER: Dottermusch M 

PROVIDER: S-EPMC12507982 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature