Multi-omics profiling reveals key microbial and metabolic variations in ischemic stroke: insights into gut and oral microbiota.

ABSTRACT: Dysbiosis of oral and gut microbiota may influence ischemic stroke (IS) pathogenesis through immune and metabolic mechanisms. This study investigated microbial translocation between oral and gut niches and its functional metabolic impact in IS patients. A total of 57 individuals were analyzed, including 25 controls (FC/KC) and 32 IS patients (FS/KS). Samples were obtained from the gut and oral subgingival plaque. The microbiome analysis was performed using the PacBio platform 16 S rRNA full-length gene sequencing, while non-targeted metabolomics was used to assess intestinal metabolites. The oral cavity of IS patients harbored abundant periodontal pathogens, including Porphyromonas and Fusobacterium. Bacterial genera (such as Streptococcus, Neisseria, Ligilactobacillus, Leptotrichia, Blaut

SUBMITTER: Yao L 

PROVIDER: S-EPMC12508004 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature