CD68- and CD163-positive tumor-associated macrophages in renal clear cell carcinoma.

ABSTRACT: This study aimed to analyze the infiltration of tumor-associated macrophages (TAMs) in clear cell renal cell carcinoma (ccRCC) and to assess their Prognostic significance. This study involved a Cohort of 106 patients with ccRCC who underwent partial or radical nephrectomy. Immunohistochemistry (IHC) was employed to assess the expression of two distinct types of macrophages at various tissue locations. The diagnostic utility of CD68-positive (CD68⁺) and CD163-positive (CD163⁺) macrophages was determined via Kaplan-Meier with log-rank tests and Multivariable Cox regression. Compared with those in adjacent tissues, the numbers of CD68⁺ and CD163⁺ TAMs were significantly elevated in ccRCC tissues. Kaplan-Meier analysis demonstrated that high CD163

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12508087 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature