Molecular mediators of cold adaptation in mammalian cells.

ABSTRACT: Hypothermia is defined as a drop in temperature below the homeostatic range of cells and tissues. This elicits a response in mammalian cells geared towards cellular and metabolic adaptation. Hibernating mammals provide natural models of cold tolerance and adaptation. Mammalian cells across species share signaling mechanisms for adaptation to hypothermic stimuli. Key molecular mediators of hypothermic signaling, including: (i) cold-sensing ion channels such as TRPM8 and TRPA1, which link temperature changes to calcium signaling and thermoregulatory responses; (ii) β-adrenergic signaling and uncoupling protein 1 (UCP1)-mediated non-shivering thermogenesis in brown adipose tissue; (iii) cold-induced epigenetic modifications such as histone acetylation, DNA methylation, and enhancer activation

SUBMITTER: Dey P 

PROVIDER: S-EPMC12508088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature