A large-scale, multi-centre validation study of an AI-empowered blood-based test for multi-cancer early detection.

ABSTRACT: Cancer is a critical global health issue, especially in low- and middle-income countries (LMICs). In this study, we integrated four additional cohorts to assess the performance and robustness of an AI-empowered blood-based test (named OncoSeek) for multi-cancer early detection (MCED). It included a case-control cohort of symptomatic cancer patients, a prospective blinded study, and two retrospective cohorts conducted on two distinct platforms. Combining these with previously published one training and two validation cohorts, we evaluated OncoSeek's performance in 15,122 participants (3029 cancer patients and 12,093 non-cancer individuals) from seven centres in three countries, using four platforms and two sample types. OncoSeek showed adequate performance for MCED with an area under the cu

SUBMITTER: Shen Y 

PROVIDER: S-EPMC12508103 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature