Trajectory of frailty and association with adverse outcomes in patients with end-stage kidney disease over the first year of dialysis.

ABSTRACT: Little is known about trajectory of frailty as patients with advanced chronic kidney disease transition onto dialysis. This retrospective cohort study aims to describe change in frailty from dialysis initiation over the course of the first year of treatment. Secondly, we aim to examine the association of frailty and change in frailty over time with mortality and hospitilisation. The study included incident haemodialysis or peritoneal dialysis patients. Clinical frailty scale (CFS) was recorded at dialysis start and after 6 and 12 months of treatment. Multilevel mixed effects linear regression models were used to examine change in CFS from baseline to 6 and 12 months after start of dialysis. Kruskal-Wallis tests were used to assess the association between CFS with number of hospitilisations

SUBMITTER: Rosenberg KL 

PROVIDER: S-EPMC12508114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature