Brain region and cell type-specific DNA methylation profiles in association with ADHD.

ABSTRACT: Previous studies identified DNA methylation (DNAm) associations with ADHD in peripheral tissue and the brain. Given that DNAm is highly cell type-specific, it is crucial to understand which cell types are driving the DNAm differences observed in ADHD. Here, we report the first brain cell type-specific epigenome-wide association study (EWAS) for ADHD (25 individuals with ADHD, 33 individuals without ADHD) in postmortem anterior cingulate cortex (ACC) and caudate nucleus (CN) based on epigenomic deconvolution. We identified distinct cell type-specific DNAm patterns in both brain regions. On the single site level, we identified significant associations with ADHD in microglia. We identified that in the ACC most differentially methylated regions (DMRs) differences were driven by glutamatergic n

SUBMITTER: Meijer M 

PROVIDER: S-EPMC12508121 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature