Comprehensive profiling of RNA modification-related genes identifies RNA m⁷G binding protein CBP20 as a therapeutic target for tumor growth inhibition.

ABSTRACT: RNA modifications add a crucial layer to gene expression regulation, though the roles of many RNA modification-related genes in cancer remain largely unexplored. Here we profile 76 RNA modification-associated genes across nine distinct types of modification (N¹-methyladenosine, 5-methylcytosine, N⁶,2'-O-dimethyladenosine, 2'-O-dimethyladenosine, N⁷-methylguanosine, pseudouridine, uridylation, 2'-O-methylation, N⁴-acetylcytidine and adenosine-to-inosine editing) in four cancer types-breast, colon, liver and lung-through a comprehensive analysis of The Cancer Genome Atlas data. Our analysis identified three candidate genes with increased expression in cancer tissues, with elevated levels associated with poor survival across multiple cancer types: t

SUBMITTER: Cho Y 

PROVIDER: S-EPMC12508125 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature