Baicalin alleviates H₂O₂-induced oxidative stress injury in human umbilical vein endothelial cells by regulating the TNF-[Formula: see text]-mediated MAPK/ERK1/2/MPO pathway.

ABSTRACT: Preeclampsia (PE) is a leading cause of morbidity and mortality among pregnant women, postpartum mothers, and perinatal infants worldwide. Currently, there are no effective pharmacological interventions for the prevention or treatment of PE. Oxidative stress in vascular endothelial cells represents a key pathophysiological mechanism underlying PE. Baicalin, a flavonoid compound derived from the traditional Chinese medicine Scutellaria baicalensis, exhibits anti-inflammatory, antioxidant, antiapoptotic, and immunoregulatory properties. However, its potential application in PE remains insufficiently investigated. In vitro experiments were conducted to establish an oxidative stress model using human umbilical vein endothelial cells (HUVECs) exposed to hydrogen peroxide. Transcriptomic analysi

SUBMITTER: Cao J 

PROVIDER: S-EPMC12508144 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature