Loss of PCAF in proximal tubular cells exacerbates renal fibrosis by promoting partial epithelial-to-mesenchymal transition.

ABSTRACT: Renal fibrosis is a consequence of chronic kidney disease, which is estimated to affect 10-14% of the global population. The molecular mechanisms in the pathogenesis of renal fibrosis are still unclear, and there is a lack of effective therapies. Here we identified decreased levels of p300/CBP-associated factor (PCAF) in kidney tissues with fibrosis and demonstrated that PCAF-specific knockout in proximal tubular cells accelerates renal fibrosis in both unilateral ureteral obstruction surgery and folic acid-induced models. Conversely, overexpressing PCAF in the kidney using adenovirus mitigated unilateral ureteral obstruction-induced renal fibrosis. Importantly, PCAF inhibits the epithelial-to-mesenchymal transition of proximal tubular cells by transcriptionally activating adherens junctio

SUBMITTER: Kim H 

PROVIDER: S-EPMC12508231 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature