Associations of TNF-α Expression With Self-Esteem in Autism Spectrum Disorder.

ABSTRACT:

Aim

This study aimed to explore the relationship between self-esteem and tumor necrotic factor-alpha (TNF-α) expression in individuals with autism spectrum disorder (ASD). Self-esteem was assessed using the Contingencies of Self-Worth (CSW) scale, with a focus on external and internal contingencies, and TNF-α expression was measured, given its association with both ASD pathophysiology and self-esteem in prior studies.

Methods

We enrolled 51 high-functioning individuals with ASD and 34 typically developed (TD) individuals. Self-esteem was assessed using the Japanese version of the CSW scale, which evaluates seven domains, and the Personal Sense of Power. TNF-α expression in plasma was quantified via ELISA. Correlations of CSW scores and the Personal Sense of Power with TNF-α

SUBMITTER: Kayashima Y 

PROVIDER: S-EPMC12508256 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature