Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane-anaesthetised horses.

ABSTRACT:

Background

Dobutamine is a first-line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied.

Objectives

To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.

Study design

Randomised cross-over experimental study.

Methods

Six healthy adult horses were enrolled, including both standing and isoflurane-anaesthetised experiments with 1-week washout. Heart rate, mean arterial pressure (MAP), central venous pressure, pulmonary arterial pressure, and thermodilution cardiac output (CO) were measured at baseline and at dobutamine infusion rates of 0.5, 1, and 2 mcg/kg/min. Arterial and mixed-venous blood w

SUBMITTER: Gorenberg EB 

PROVIDER: S-EPMC12508280 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature