Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction.

ABSTRACT:

Background

Due to the high frequency of laminitis reported for both conditions, the relationship between pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID), and the potential role of dopamine in modifying insulin secretion, requires further investigation.

Objectives

To evaluate the effect of pergolide mesylate on insulin sensitivity and postprandial insulin and glucose responses in horses and ponies with ID, both with or without concurrent PPID.

Study design

Randomised crossover study.

Methods

Sixteen horses and ponies, comprising eight matched pairs (PPID+ID or ID-only), were given pergolide mesylate at a dose of 2 μg/kg bwt orally once daily for 4 weeks (plus a 4-week non-treatment control period, with a 4-week washout between phases)

SUBMITTER: Galinelli NC 

PROVIDER: S-EPMC12508286 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature