Assessment of tree-associated atypical myopathy risk factors in Acer pseudoplatanus (sycamore) seeds and leaves.

ABSTRACT:

Background

Sycamore tree-derived hypoglycin A (HGA) toxin causes atypical myopathy (AM), an acute, equine pasture-associated rhabdomyolysis but incidence fluctuates.

Objectives

Investigate whether tree or environmental factors influence HGA concentration in sycamore material and are associated with AM relative risk.

Study design

Retrospective and experimental prospective study.

Methods

UK sycamore population, seed production and AM incidence data were obtained. HGA concentration was measured in seeds from trees from 10 different central UK locations. The effect of tar spot infection, seed maturity, tree trunk girth, location (urban/countryside), AM cases within 130 m, soil type, facing direction of seeds on the tree and year on seed HGA concentration was examin

SUBMITTER: Gonzalez-Medina S 

PROVIDER: S-EPMC12508288 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature