Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism.

ABSTRACT:

Background

Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to translate and validate the PHPQoL for Dutch use and to evaluate the effect of PTx on HRQoL in both symptomatic and asymptomatic PHPT patients.

Methods

In this single-center prospective study, PHPT patients with at least one surgical indication underwent either PTx or conservative treatm

SUBMITTER: Zhang JLH 

PROVIDER: S-EPMC12508306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature